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年輕女子米歇爾（瑪麗·伊麗莎白·溫斯特德 Mary Elizabeth Winstead 飾）不久前剛和男友發(fā)生爭吵，她夜晚駕車奔馳在黑暗的公路上，突然遭遇嚴重車禍昏迷過去。當她再度醒來時，發(fā)現(xiàn)自己被綁住手腳，關在一個密閉的空間里。少頃，一個健碩冷峻的男子霍華德（約翰·古德曼 John Goodman 飾）走了進來。軍人出身的霍華德聲稱地球剛剛遭遇可怕的生化危機，地球人幾乎滅亡殆盡。他在數(shù)年前未雨綢繆修建了這個設備、資源齊全的避難所，只為生存下去。避難所內，除了霍華德、米歇爾外，還有另外一個年輕男子埃米特。米歇爾對霍華德的說辭半信半疑，她堅信自己遭到了變態(tài)狂的拘禁。 真相究竟為何？威脅無處不在……
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